【摘要】 目的探讨早产儿脑室周围白质软化(PVL)的高危因素、发病机制及其早期诊断方法。方法采集PVL早产儿宫内缺氧缺血病史;采用ELISA检测PVL早产儿脐血TORCH-IgM抗体;应用硝酸还原酶法检测脐血一氧化氮(NO)水平。结果PVL组52例早产儿中39例有宫内缺氧缺血病史且脐血TORCH-IgM抗体阳性率明显高于对照组(P<0.05);PVL组脐血NO水平明显高于对照组(P<0.05)。结论宫内缺氧缺血和感染是早产儿PVL的高危因素。过量NO可能在PVL发生机制中起重要作用;脐血NO水平检测对早产儿PVL有早期诊断价值。更多还原

【Abstract】 Objective To explore the high risk factors, pathogenesis and methods of early diagnosis of periventricular leukomalacia(PVL) in premature infants.Methods The history of intrauterine hypoxia-ischemia was investigated in premature infants;TORCH-IgM antibodies in cord blood of premature infants were measured by ELISA; Nitric oxide (NO) levels in their cord blood were determined by nitric acid reducing enzyme means. Results Thirty-nine of 52 premature infants in PVL group had a history of intrauterine hypoxia-ischemia; TORCH-IgM antibody positive rate in cord blood of premature infants in PVL group was significantly higher than that in control group(P< 0.05 );NO level in their cord blood was significantly higher than that in control group (P<0.05).Conclusions Intrauterine hypoxia ischemia and infection are two high risk factors of PVL in premature infants.Excessive NO maybe play a key role in development of PVL in premature infants.Determination of NO level in cord blood is valuable to early diagnosis of PVL in premature infants.更多还原