【摘要】 目的探讨胃癌及癌前病变中碱性成纤维细胞生长因子(bFGF)、成纤维细胞生长因子受体-2(FG-FR-2)及乙酰肝素酶(Hpa)的表达及其与胃癌发生发展的关系。方法选择广西医科大学第一附属医院2001—2005年手术切除和内镜活检的胃黏膜标本145例,其中慢性浅表性胃炎(CSG)组30例、胃黏膜肠上皮化生(IM)组29例、不典型增生(Dys)组31例、胃癌(GC)组55例,采用免疫组化SP法检测各组bFGF、FGFR-2及Hpa的表达。结果bFGF、FGFR-2的表达CSG组低于其余3组(P<0.05),IM组低于Dys组和GC组(P<0.05);Hpa在GC组表达显著高于其他3组(P<0.01);bFGF、FGFR-2及Hpa的表达与胃癌浸润深度、淋巴结转移、远处转移及TNM分期有关(P<0.01)。结论bFGF、FGFR-2及Hpa可能参与胃癌的发生发展过程,并可能加速胃癌的浸润和转移。更多还原

【Abstract】 Objective To study the expression of basic fibroblast growth factor(bFGF),fibroblast growth factor receptor-2(FGFR-2)and heparanase(Hpa)in the tissues of gastric cancer and precancerous lesions,and to explore its significance in the carcinogenesis and malignant progression of stomach.Methods The expression of bFGF,FGFR-2 and Hpa were detected by immunohistochemistry in 145 cases of paraffin-embedded specimens from different gastric mucosa,including 30 cases of chronic superficial gastritis(CSG),29 of intestinal metaplasia(IM),31 of dysplasia(Dys)and 55 of gastric carcinoma(GC).Results The expression of bFGF and FGFR-2 in CSG group was significantly lower than that of the other three groups(P<0.05),and was significantly lower in IM group than that of Dys and GC groups(P<0.05).The Hpa expression in GC group was significantly higher than that of the other three groups(P<0.01).There was close relationship between the expression of bFGF,FGFR-2 and Hpa and the invasive depth,lymph node metastasis,distant metastasis and TNM staging of GC(P<0.01).Conclusion bFGF,FGFR-2 and Hpa are involved in the carcinogenesis and development of gastric carcinoma.更多还原