【摘要】 目的探讨慢性咳嗽患者小气道病变与气道高反应性的相关性及其对早期哮喘的预测价值。方法对广东省中医院呼吸科2004年9月至2006年9月就诊的249例慢性咳嗽患者,用肺功能检测判断有无小气道病变,用支气管激发试验检测其气道反应性;进一步分析小气道病变与气道高反应性之间的相关性及与患者年龄之间的关系。结果249例慢性咳嗽患者中91例有小气道病变,103例患者支气管激发试验阳性;有小气道病变患者的支气管激发试验阳性率(73.63%,67/91)较无小气道病变患者(22.78%,36/158)明显增高,差异有显著性意义(P<0.01)。小气道病变患者中,<40岁组的激发试验阳性率(90.0%,27/30)明显高于≥40岁组(65.57%,40/61),差异有显著性意义(P<0.05)。结论小气道病变是气道高反应性患者的重要特征,可以用来发现早期年轻哮喘患者。更多还原

【Abstract】 Objective The aim of this study is to investigate the correlation between small airway disease and airway hyper-responsiveness,and explore the predicting value of small airway diseases for asthma.Methods Pulmonary function tests and bronchial provocation tests were performed in 249 patients with chronic cough from Sep. 2004 to Sep. 2006.The incidence of small airway disease and airway hyper-responsiveness were observed.Results There were 91 patients with small airway disease,and 103 patients with positive tests for bronchial provocation in total 249 chronic cough patients.The incidence of positive tests for bronchial provocation in 91 patients(73.63%)with small airway disease was significantly higher than that in 158 patients(22.78%)without it,P<0.01.Also,there was a significant difference in the incidence of positive tests for bronchial provocation in patients with small airway diseases between less than 40 years old and no less than 40,90.0% vs 65.57%,P<0.05.Conclusion The small airway disease is an effective predicting factor for asthma,especially to those young patients with chronic cough.更多还原