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粪便抗原检测诊断儿童幽门螺杆菌感染的临床评估

Stool Hp antigen test for diagnosis of Hp infection in children

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【作者】 步革李楠程艳波李微郝兰

【Author】 BU Ge1, LI Nan2, CHENG Yan-bo1, et al. 1 Department of Laboratory ;2 Department of Digestion,Kaifeng Children’s Hospital,Kaifneg Henan 475000,China

【机构】 开封市儿童医院检验科开封市儿童医院消化科开封市儿童医院检验科 河南开封475000河南开封475000

【摘要】 目的幽门螺杆菌粪便抗原(HpSA)检测诊断儿童幽门螺杆菌(Hp)感染的准确性,方法对64例因上消化道症状的患儿进行病理组织学、快速尿素酶试验(RUT),以确定是否感染Hp。结果以病理组织Giemse染色检查结果作为诊断Hp感染的金标准。粪便抗原检测的敏感性是88.8%,特异性93.3%,准确性90.6%,阳性预测值93.7%,阴性预测值84.8%。结论粪便抗原检测有较高的敏感性和特异性,是一种测定小儿HP感染可靠易行的非侵入性诊断方法。

【Abstract】 Objective To investigate the accuracy of stool helicobacter Pylori (Hp) antigen test (HpSA) in the diagnosis of Hp infection.Mehtods Sixty-four children with upper digestive tract symptom were tested for Hp with histopathology and fast urase test.Results By use of histopathology as gold standard, the sensitivity of HpSA in the diagnosis of Hp infection was 88.89% and the specificity was 93.3%, the positive predictive value, negative predictive value and the diagnositic accuracy were 97.7%, 84.8% and 89.1%, respectively.Conclusion Stool Hp antigen test is a reliable and noninvasive method for detection of Hp infection of children with a high sensitivity and specificity.

【关键词】 幽门螺杆菌粪便抗原检测儿童
【Key words】 Helicobacter PyloriStool antigen testChildren
  • 【文献出处】 临床和实验医学杂志 ,Journal of Clinical and Experimental Medicine , 编辑部邮箱 ,2007年09期
  • 【分类号】R725.7
  • 【被引频次】1
  • 【下载频次】71
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