【摘要】 目的探讨门冬胰岛素30(诺和锐30)短期强化治疗对伴有明显高血糖的初诊2型糖尿病(T2DM)患者的疗效及胰岛功能的影响。方法对40例初诊2型糖尿病患者在饮食和运动治疗基础上给予诺和锐30强化治疗12周,分析比较治疗前后空腹血糖(FPG)、空腹胰岛素(FINS)、空腹C肽(F-C)、糖化血红蛋白(HbAlc)、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、体质指数(BMI)、餐后2小时血糖(2hPG)、餐后2小时胰岛素(2h-INS)、餐后2小时C肽(2h-C)、胰岛素分泌指数(HOMA-IS)、胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)和FINS/FPG比值的变化。结果40例患者血糖达标时间为(8.3±1.5)d,治疗后FPG、2hPG、HbAlc、TC、TG、LDL-C、HOMA-IR较治疗前均有显著下降(P<0.05),HDL、FINS、2h-INS、F-C、2h-C、HOMA-IS、ISI、FINS/FPG较治疗前明显升高(P<0.01),BMI稍有增高,但差别无统计学意义,治疗过程中无严重不良反应。结论对伴有明显高血糖的初诊T2DM患者,用诺和锐30强化降糖,可保护胰岛β细胞功能,间接改善血脂紊乱。更多还原

【Abstract】 Objective To investigate the effect of insulin aspart 30 intensive treatment on plasma glucose and pancreatic function in patients with newly diagnosed type 2 diabets.Methods Forty patients with newly diagnosed type 2 diabetes were treated with insulin aspart 30 for 12 weeks.An oral glucose tolerance test was performed before and after treatment.The level of fasting plasma glucose(FPG),fasting serum insulin(FINS),fasting C-peptide(F-C),glycosylated hemoglobin Alc(HbAlc),total cholesterol(TC),low-density lipoprotein-cholesterol(LDL-C),triglyceride(TG),high-density lipoprotein-cholesterol(HDL-C),2 hours postprandial plasma glucose(2hPG),2 hours postprandial C-peptide(2h-C),2 hours postprandial insulin(2h-INS),body mass index (BMI),insulin resistance index(HOMA-IR),insulin secretion index(HOMA-IS),insulin sensitivity index(ISI) and ratio of fasting insulin to fasting glucose( FINS/FPG) were compared before and after insulin aspart 30 treatment.Results After treatment,FPG,2hPG,HbAlc,TC,TG,LDL-c and HOMA-IR were significantly decreased(P < 0.05);while HDL-C,FINS,2h-INS,F-C,2h-C,HOMA-IS,ISI and FINS/FPG were significantly increased(P < 0.01).Conclusion Insulin aspart 30 intensive treatment can satisfactorily control plasma glucose level,improve β-cell function and blood lipid disturbance in patients with newly diagnosed type 2 diabetes.更多还原