【摘要】 目的比较复发性上皮性卵巢癌患者应用紫素加铂类(TP组)与环磷酰胺加铂类(PC组)方案化疗的疗效及费用。方法我院1998年1月至2003年1月收治的符合入选标准的复发性上皮性卵巢癌患者39例,其中TP方案化疗24例,PC方案化疗15例。对2组在总生存率、中位生存时间、药物反应率、不良反应、住院费用等方面进行回顾性分析。结果TP组复发后中位生存时间为28．64月,PC组中位生存时间为17．29月,2组比较,差异有统计学意义(P＜0．05);TP组及PC组复发患者化疗后有效反应持续时间中位数分别为25．02月和1．40月,2组比较,差异有统计学意义(P＜0．05);2组消化系统不良反应比较,Z=—0．422(P＜0．05),2组血液系统均无Ⅳ度不良反应发生;TP组医疗费用为62934元,PC组为22 497元,2组比较,差异有统计学意义(P＜0．05),TP组每生存1年,平均住院费用为64 641元,PC组每生存1年,平均住院费用为21 318元。结论紫素加铂类作为复发性卵巢癌的首选化疗方案,患者化疗后有效率、复发后生存时间及有效反应持续时间等方面优于环磷酰胺加铂类组,而化疗费用亦高于PC组。更多还原

【Abstract】 Objective To compare the efficacy and costs in recurrent ovarian epithelial cancer treated with paclitaxel plus platinum(TP regimen)and cyclophosphamide plus platinum(PC regimen).Methods 39 cases with recurrent epithelial ovarian cancer treated in our hospital during January 1998 to January 2003 were selected according to inclusion criteria.Twenty four cases were under ewent TP regimen and 14 cases PC regimen.These recurrent patients were analyzed retrospectively.Results The medians the survival time for TP regimen group and PC regimen group were 28.64 months and 17.29 months,respectively(P＜0.05).The medians of effective time after to chemotherapy were 25.02 months and 1.40 months respectively(P＜0.05).The digestive system toxicity was higher in TP than in PC(P＜0.05).The average cost per survival year was 64 641 Chinese Yuan for TP regimen and was 21 318 Chinese Yuan for PC regimenone(P＜0.05). Conclusion As the first selective regimen for recurrent ovarian epithelial cancer,TP regimen is super to PC regimen in efficiency,survival time and duration of effective response,but the costs of TP is higher than PC.更多还原