【摘要】 目的研究国产乙烯-乙烯醇(EVAL)聚合物栓塞动物模型的技术可行性及栓塞效果。方法家猪6头,体重25~30kg,雌雄不限,全麻下,超选择插管至咽升动脉/奇网(retemirable,RMB),在持续透视下,缓慢注入国产EVAL聚合物,对血管进行栓塞,直至满意为止。对猪进行随观,随观期限分别为1d、1周、4周、8周、12周、24周,随观内容包括DSA复查、大体标本及组织病理学观察。结果所有的动物均成功进行了栓塞,除1头家猪由于返流过度“挤管”外,其余的栓塞及拔管顺利,造影显示所有的栓塞血管均未显影。大体标本显示血管内可见黑色栓塞物铸型,自尾侧向头端弥散,质实,容易剥离。病理显示急性期血管壁不同程度的破坏,栓塞剂周围及血管外可见中性粒细胞及嗜酸性粒细胞浸润以及大量的红细胞;亚急性期及慢性期可见单核细胞浸润和不同程度的肉芽组织/纤维化。结论作为非黏附性液体栓塞材料,EVAL聚合物是一种具有栓塞可控性好,易判断栓塞的开始和终结点的较理想栓塞物。更多还原

【Abstract】 Objective To study the technical feasibility and embolic effect of embolism with the national ethylene-vinyl alcohol copolymer(EVAL)embolic mixture in an animal model.Methods 6 swines,25~30 kg,no matter male or female were used in this study.Superselective catheterization of ascending pharyngeal artery or rete mirable(RMB) was performed under general anaesthesia,then EVAL embolic mixture was injected to make the vascular embolism until satisfaction under fluoroscopy.The swines after embolism were followed-up 1 day,1 week,4 weeks,8 weeks,12 weeks,24 weeks and DSA,histopathological examination were respectively done.Results The embolic programes were successful in all animals,but one because of over reflux,and the embolic blood vessels could not be showed on angiography.In gross pathology,black embolic EVAL inside the vessels could be seen,which were firm and easily dissected.In histopathology,in the acute phase,all of vessel walls were destroyed in different degree,there were many neutrophils and eosinophils around the EVAL embolic mixtures and out of the vessels,and a lot of red cells could be seen,in subacute and chronic phase,mild to moderate mixed inflammatory infiltrates with histoleucocytes and large foreign-body giant cells were seen in occluded vessels.Conclusion The national EVAL embolic mixture is a suitable and easy control vascular embolic material.更多还原