节点文献

放化疗综合治疗直肠癌术后局部复发38例疗效分析

Clinical Analysis of Radiotherapy Plus Chemotherapy for Postoperative Local Recurrent Colorectal Carcinoma

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 郑安平赵一电赵福军孙荣刚张广彬王东果

【Author】 ZHAO An-ping,ZHAO Yi-dian,ZHAO Fu-jun,et al.Anyang Cancer Hospital,Anyang,455000

【机构】 河南省安阳市肿瘤医院放一科河南省安阳市肿瘤医院放一科

【摘要】 目的评价放射治疗同期应用L-OHP联合5-Fu/LV治疗直肠癌术后局部复发患者的疗效及毒副作用。方法2000年5月至2003年6月对收治的38例术后局部复发直肠癌患者,在放射治疗的同期应用L-OHP联合5-Fu/LV治疗3~6个周期:放疗期间化疗2个周期,放疗后继续化疗1~4个周期,放疗剂量为60~68Gy/7周,并进行回顾性分析。结果1、2、3年生存率分别为84%、61%、37%;1、2、3年局部控制率分别为65%、53%、45%,同时其治疗相关不良反应有所增加,但大部分为1、2级,未见4级治疗不良反应发生。治疗失败的原因为肿瘤远处转移及局部复发。结论放射治疗的同期应用L-OHP联合5-Fu/LV治疗直肠癌术后复发是1种安全、有效的治疗模式。

【Abstract】 Objective To evaluate the efficacy and toxicities of concurrent radio-chemotherapy of oxaliplatin with 5-flurouracil and leucovorin in postoperative local recurrent colorectal carcinoma .Methods 38 patients with postoperative local recurrence from colorectal carcinoma were treated with radiotherapy and oxaliplatin, 5-flurouracil and leucovorin. 3 to 6 cycles of chemotherapy were given, in which 2 cycle were used concurrently with radiotherapy and 1~4 cycles were given after concurrent radiochemotherapy. The dose of radiotherapy was 60~68 Gy in 7 weeks. Results The overall 1-, 2-, and 3-year survival rates were 84%, 61%, and 37%. The overall 1-, 2-, and 3-year local control rates were 65%, 53%, and 45%. Treatment related toxicities were increased, but there were no grade Ⅳ side effects.The main causes of treatment failure included distant metastasis and local recurrence. Conclusion Concurrent radiochemotherapy with oxaliplatin, 5-flurouracil and leucovorin was effective and safe in the treatment of postoperative local recurrent colorectal carcinoma.

【关键词】 直肠癌放疗化疗
【Key words】 Rectal carinomaRadiotherapyChemotherapy
  • 【文献出处】 实用癌症杂志 ,The Practical Journal of Cancer , 编辑部邮箱 ,2007年04期
  • 【分类号】R735.37
  • 【被引频次】5
  • 【下载频次】84
节点文献中: 

本文链接的文献网络图示:

本文的引文网络