【摘要】 目的评价放射治疗同期应用L-OHP联合5-Fu/LV治疗直肠癌术后局部复发患者的疗效及毒副作用。方法2000年5月至2003年6月对收治的38例术后局部复发直肠癌患者,在放射治疗的同期应用L-OHP联合5-Fu/LV治疗3~6个周期:放疗期间化疗2个周期,放疗后继续化疗1~4个周期,放疗剂量为60~68Gy/7周,并进行回顾性分析。结果1、2、3年生存率分别为84%、61%、37%;1、2、3年局部控制率分别为65%、53%、45%,同时其治疗相关不良反应有所增加,但大部分为1、2级,未见4级治疗不良反应发生。治疗失败的原因为肿瘤远处转移及局部复发。结论放射治疗的同期应用L-OHP联合5-Fu/LV治疗直肠癌术后复发是1种安全、有效的治疗模式。更多还原

【Abstract】 Objective To evaluate the efficacy and toxicities of concurrent radio-chemotherapy of oxaliplatin with 5-flurouracil and leucovorin in postoperative local recurrent colorectal carcinoma .Methods 38 patients with postoperative local recurrence from colorectal carcinoma were treated with radiotherapy and oxaliplatin, 5-flurouracil and leucovorin. 3 to 6 cycles of chemotherapy were given, in which 2 cycle were used concurrently with radiotherapy and 1~4 cycles were given after concurrent radiochemotherapy. The dose of radiotherapy was 60~68 Gy in 7 weeks. Results The overall 1-, 2-, and 3-year survival rates were 84%, 61%, and 37%. The overall 1-, 2-, and 3-year local control rates were 65%, 53%, and 45%. Treatment related toxicities were increased, but there were no grade Ⅳ side effects.The main causes of treatment failure included distant metastasis and local recurrence. Conclusion Concurrent radiochemotherapy with oxaliplatin, 5-flurouracil and leucovorin was effective and safe in the treatment of postoperative local recurrent colorectal carcinoma.更多还原