【摘要】 目的研究CD44V5蛋白在胃癌组织中的表达,并探讨胃癌浸润和转移的分子机制。方法采用免疫组化方法检测60例手术切除的胃癌及癌旁组织标本中CD44V5蛋白表达情况。结果CD44V5在胃癌组织中表达率为48.3%,在癌旁组织中表达率为10.0%(χ2=21.3378,P(0.05)。在慢性浅表性胃炎组织中无表达。有淋巴结转移组显著高于无转移组(P(0.05);CD44V5表达与胃癌分期和分化程度无关。结论胃癌组织中CD44V5蛋白表达率增高,与胃癌的转移相关,可作为判断胃癌恶性程度和预测预后的参考指标。更多还原

【Abstract】 Objective To investigate the expression of CD44V5 proteins in gastric cancer and to explore the mechanism of invasion and metastasis of gastric cancer. Methods 60 paraffin-embedded samples of gastric cancer and para-cancer from surgically resected tissues, 15 biopsy samples of chronic surface gastritis were served as controls. The expression of CD44V5 protein was examined by immunohistochemical method. Results The positive expression rates of CD44V5 protein in samples from cancerous and paracancerous tissues were 48.3% and 10%, respectively. The expression rate was zero in the control tissues. The expression rates of CD44V5 in cancerous tissue were significantly higher than those of para-cancer tissue(P〈0.05). The expression of CD44V5 protein correlated statistically with the lymph node metastasis and cancer stage. Conclusion The expression of CD44V5 are correlated to invasion and metastasis of gastric cancer. It could be used as marker to predict metastasis and invasion of gastric cancer and as a prognostic factor as well.更多还原