【摘要】 目的:探讨p73基因在急性淋巴细胞白血病(ALL)和多发性骨髓瘤(MM)发生发展中的机制。方法:应用RT-PCR技术检测58例ALL患者和40例多发性骨髓瘤的p73基因mRNA表达情况,并结合患者的临床资料进行分析。结果:58例ALL患者中,p73mRNA阴性表达率为32.8%(19/58),40例MM患者p73mRNA均阳性表达。p73mRNA阴性表达与ALL患者首次化疗既获完全缓解及平均缓解时间的降低有明显关系。结论:p73mRNA检测对判断ALL患者预后有一定的意义。p73基因异常可能不是MM发病的重要分子事件。更多还原

【Abstract】 Objective:To investigate the relationship between p73 gene and the development and progression of acute lymphoblastic leukemia(ALL) and multiple myeloma(MM).Methods:The levels of p73 transcripts in 58 ALL and 40 MM patients were assayed using reverse transcriptase-polymerase chain reaction(RT-PCR) and their relationship with the clinicopathological characteristics was analyzed.Results:Of the 58 ALL patients 19 showed negative expression of p73 mRNA.The negative rate was 32.8%.All MM patients showed positive expression.Loss of p73 expression was significantly associated with the reduced average remission duration and the frist chemotherapy complet remission rate.Conclusion:Examination of p73 mRNA might have clinical significance in predicting prognosis of ALL.Abnormal expression of the p73 gene may be not a significabnt event in the devlopment pf MM.更多还原