【摘要】 目的:评价奈达铂和氟尿嘧啶化疗联合同步放疗治疗Ⅲ、Ⅳa期鼻咽癌的局控率、生存率和毒副反应。方法:回顾性分析奈达铂+氟尿嘧啶化疗联合同步放疗治疗Ⅲ、Ⅳa期鼻咽癌30例的局控率、生存率和毒副反应,并与单纯放疗30例相比较。结果:CR率放化组为93.33%,单放组为73.33%,两组比较差异有统计学意义(P<0.05);1年无复发生存率和1年无远处转移生存率放化组分别为93.33%和86.67%,单放组分别为83.33%和73.33%,两组比较差异无统计学意义(P>0.05);治疗毒副反应:放化组恶心呕吐高于单放组,主要是轻中度,差异有统计学意义(P<0.05);放化组骨髓抑制较单放组明显(P<0.05),且放化组有1例在第3周期化疗后发生Ⅳ度血小板下降;放化组皮肤反应无明显加重(P>0.05),但Ⅲ、Ⅳ度口腔黏膜反应与单放组比较差异有统计学意义(P<0.05)。结论:奈达铂+氟尿嘧啶同期放化疗治疗Ⅲ、Ⅳa期鼻咽癌近期疗效确切,毒副反应较低,患者耐受性良好。更多还原

【Abstract】 Objective: To evaluate the rates of local control,survival and toxicity of nedaplatin and fluorouracil(5-Fu) chemotherapy in combination with radiotherapy for stage III and IVa nasopharyngeal carcinoma(NPC).Methods: To analyze the rates of local control,survival and toxicity of 30 patients treatd by nedaplatin and fluorouracil chemotherapy in combination with radiotherapy for stage III and IVa nasopharyngeal carcinoma,and compare with the 30 patients treated by radiotherapy.Results: The complete remission(CR) rate in chemo-radiotherapy group was 93.33%.And in radiotherapy group was 73.33%.There was signifcant difference between them(P<0.05).The 1-year free from local regional failure survival rate and the 1-year free-distant metastasis survival rates of chemo-radiotherapy group were 93.33% and 86.67%.90% and 80% in radiotherapy group.There was no difference between them(P>0.05).Side effects: the nausea and vomiting caused in chemo-radiotherapy group was higher than it in radiotherapy group,(P<0.05);The marrow suppression in chemo-radiotherapy group was more obvious than it in radiotherapy group(P<0.05),and one case of chemo-radiotherapy group leads to IVO thrombocytopenia after third cycles of chemotherapy;The reaction of skin in chemo-radiotherapy group was no difference in statistics(P>0.05),but compare III and IV oral macostis in chemo-radiotherapy group with radiotherapy group,there was difference in statistics(P<0.05).Conclusion: Nedaplatin and 5-Fu chemotherapy combined with radiotherapy for nasopharyngeal carcinoma of stage III and IVa showed higher efficacy and low toxicity,and most patients are tolerated the therapy well.更多还原