【摘要】 目的评价后程立体定向适形放疗加化疗治疗食管癌的疗效。方法从2001年4月~2002年4月我科对46例住院的食管癌患者进行后程立体定向放疗加化疗,即先常规放疗前后野垂直照射40Gy后,改立体定向适形放疗加量20~30Gy/6~7周,并在整个放疗过程的前、中、后各化疗(PF方案)1周期,共3周期(治疗组);同期全院共常规放疗106例(对照组),即先常规照射(前后两垂直野)放疗40Gy后,改等中心(避开脊髓)照射加量20~30Gy/6~7周,6~15MV-X线照射。结果治疗组、对照组近期有效率分别为88.8%、78.3%,1、3年局控率、生存率分别为73.3%、57.8,62.5%、43.2和73.3%、51.1%,61.5%、38.4%。(P>0.05)治疗组消化道反应及骨髓抑制发生率明显高于对照组,经对症支持治疗后能完成治疗。结论后程立体定向适形放疗加化疗能提高中晚期食管癌的有效率、生存率,毒副反应能耐受。更多还原

【Abstract】 Objective: To evaluate the curative effect of late course stereotactic conformal radiotherapy combined with chemotherapy in the treatment of esophageal carcinoma. Methods: Forty-six patients(treatment group) were treated by late-course stereotactic conformal radiotherapy from April 2001 to April 2002. The treatment regimen consisted of conventional radiotherapy first (40Gy , perpendicular A-P portals),followed by stereotactic conformal radiotherapy (20~30Gy/6~7w) combined with three cycles chemotherapy(DDP +5-Fu).One hundred and six patients (control group ) were treated by conventional radiotherapy (40Gy , perpendicular A-P portals and 20~30Gy iso-center). 6~15 MV X-rays were adopted. Results: In the treatment group and control group the recent effective rate were 88.9% and 78.3%.The 1,3 year local control and overall survival rateswere 73.3%, 57.8%;62.5% ,43.2% and 73.3%,51.1%;61.5%,38.4%(P>0.05 ).The gastrointestinal tract toxicities and bone marrow inhibition in control group were obviously,and all patients completed the planned treatment with expectant treatment. Conclusion: Late cours stereotactic conformal radiotherapy combined with chemotherapy can raise the effective rate and overall survival rate in middle late stage esophageal carcinomas.更多还原