【摘要】 目的探讨经颈外动脉灌注化疗在鼻咽癌放疗前的临床应用价值。方法在局麻下行颈外动脉安置药盒术,并在X线机造影下了解肿瘤供血动脉支,证实颈内外动脉无交通支,经药盒灌注化疗药,主要药物顺铂、5-氟脲嘧啶和平阳霉素,一周后拆线,给常规放疗,DT40Gy/20f/4w,再灌注一次,最后连续放疗,总量达DT62Gy/31f/6.2w,与常规放疗30例作对照。结果治疗组完全缓解率为66.66%,对照组完全缓解率为53.33%,治疗组放射剂量低于对照组,毒副反应较重,但对症治疗能耐受。结论鼻咽癌放疗前经颈外动脉安置药盒灌注化疗药临床应用,简便、安全、有效。更多还原

【Abstract】 Objective: To evaluate the value of trans-external cavotid infusion chemotherapy for nasopharyngeal carcinoma before radiotherapy. Methods: Nasopharyngeal carcinoma was treated by medical box, installed trans-external carotid in Iocal anaesthesia, infusion chemotherapy of cisplatin, 5-fluorouracil and pingyangmycin. Through the x-ray arterial develop conventional radiotherapy. DT was 40Gy/20f/4w started and took out stitches one week after internal chemotherapy. Trans-external carotid infusion chemotherapy was taken once again, then, continuing radiotherapy in order to the totol DT reached to 62Gy/31f/6.2w, 30 nasopharyngeal carcinoma patients treated with radiotherapy alone as control. Results: Complete response rate in the two groups , chemotherapy before radiotherapy and radiotherapy alone, were 66.66% and 53.33% respectively. The poison and side effect was more seriously than that of radiotherapy alone. Conclusion: Trans-external carotid infusion chemotherapy by installing medical box for nasopharyngeal carcinoma before radiotherapy is effective.更多还原