【摘要】 目的:观察氨磷汀对血液恶性肿瘤化疗患者肝脏保护作用及药物的安全性。方法:将18例血液恶性肿瘤患者合并病毒性肝炎或既往化疗肝脏不能耐受者,分为对照组(单纯化疗)和治疗组(化疗加阿米福汀),作自身前后对照研究,化疗前后监测肝功能,同时观察药物不良反应。结果:化疗相关肝功能损害对照组出现18例,治疗组出现3例(P<0.01)。结论:氨磷汀能明显减少化疗相关的肝功能损害,且不良反应少见。更多还原

【Abstract】 Objective: To study the protection of hepatic toxicity by amifostine on hematological malignamt patients receiving chemotherapy and its adverse reaction. Methods: Eighten patients were treated by two kinds of treatments one was chemotherapy (control group),the other was chemotherapy plus amifostine(treatment group). Liver function was observed before and after chemotherapy. Results: Liver function damage occurred in 3 patients in treatment group and 18 patients in control group (P<0.01).Conclusion: Amifostine can apparently reduce the damage of hepatic function of patients caused by cytotoxicticagens ,its side effect is not obvious.更多还原