【摘要】 目的制备复方黄芩巴布剂并进行透皮释放度的测定。方法正交设计法对巴布剂基质配比进行的实验研究;应用自制的透皮释放扩散池装置进行透皮释放度研究,高效液相色谱法测定释放液中黄芩苷的含量。结果复方黄芩巴布剂基质以阿拉伯胶∶西黄蓍胶∶压敏胶∶甘油∶氧化锌=2∶1∶1∶0.1∶0.3为最适宜;24 h的透皮释放量为(450±30)ng/cm2。结论该制备工艺简单,制成的巴布剂黏性适中、质量可控、释药稳定。更多还原

【Abstract】 Objective To prepare the complex scutellariae baicalensis cataplasm and to determine transdermal release.Methods The orthogonal design wad used to optimize the matrix formulation.The transdermal release was determined by a self-designed diffusion cell system,and the content of baicalin was detected by HPLC.Results The matrix formulation of the complex scutellariae baicalensis cataplasm was made with gum acacia∶gum tragacabth∶gum stamp sensitive∶glycerine∶zinc oxide=2∶1∶1∶0.1∶0.3.The 24 h accumulative release was(450±30)ng/cm~2. Conclusion The preparation of complex scutellariae baicalensis cataplasm is simple,the stickness is suitable,and the transdermal release is stability.更多还原