【摘要】 以L-氨基酸为手性源,合成了多种具有C2-对称的手性双-S-2-(咪唑-1-基)脂肪酰二胺并且进行了结构表征。在碱性条件下,L-氨基酸和乙二醛、甲醛经过缩合反应生成了(S)-2-(咪唑-1-基)羧酸钠,与甲醇作用转化为甲酯后继与二胺进行胺解反应制得目标分子。这些化合物可进一步合成新型手性咪唑鎓环蕃或进行配位络合、分子识别等研究。更多还原

【Abstract】 The Sodium(S)-2-(imidazol-1-yl) alkanoic acids(2) were prepared by cohydendensation reaction of natu-ral amino acids with formaldehyde water solution and glyoxal water solution under basic condition.The Sodium salts react with methyl alcohol to form(S)-2-(imidazol-1-yl) alkanoates(2).The C2-symmetric chiral bis-S-2-(imid-azol-1-yl) alkanamides were synthesized directly by amidolysis of the S-2-(imidazol-1-yl) alkanadates with biamine the structures of the compounds(3a~d,4a~c) were confirmed by IR,1HNMR,MS,and elemental analysis.更多还原