【摘要】 目的:观察3~6岁夜间哮喘患儿潮气呼吸肺功能的昼夜节律,探讨炎症介质白三烯E4(LTE4)与夜间哮喘的关系。方法:研究对象分为夜间哮喘组、哮喘非夜间发作组和健康对照组,动态测定三组患儿潮气呼吸肺功能指标达峰时间比(TPTEF/Te)、达峰容积比(VPEF/Ve),同时动态监测尿液中LTE4浓度。结果:夜间哮喘组潮气呼吸肺功能具有明显的昼夜节律,TPTEF/Te、VPEF/Ve于16:00达峰值,4:00降到低谷,二者差异有显著性(P<0.01)。于3:01~6:00段夜间哮喘组LTE4浓度显著高于哮喘非夜间发作组及健康对照组(P<0.01)。且夜间哮喘组夜间段LTE4浓度明显高于日间段(P<0.05,P<0.01)。通过直线相关分析表明,夜间哮喘组3:01~6:00段尿LTE4浓度与4:00的TPTEF/Te值呈负相关(P<0.01);与4:00的VPEF/Ve值也呈负相关(P<0.05)。结论:3~6岁夜间哮喘患儿潮气呼吸肺功能具有昼夜节律;LTE4是哮喘的重要炎症介质,且与夜间哮喘的发生密切相关。更多还原

【Abstract】 Objective:To observe the circadian rhythm of tidal breathing lung function in 3～6 years old children with nocturnal asthma and the relationship of inflammation mediator leukotriene E4(LTE4)and nocturnal asthmatic children who are 3～6 years old.Methods:The subjects were divided into three groups:nocturnal asthmatic group;non-nocturnal attacksgroup and normal control group.Tidal breathing lung function(TPTEF/Te,VPEF/Ve)was measured at 4:00,9:00,16:00,22:00.Urine was collected at 3:01～6:00,8:01～11:00 and 15:01～18:00.The level of LTE4 was measured by ELISA.Results:In nocturnal asthmatic group tidal breathing lung function(TPTEF/Te,VPEF/Ve)were highest at 16:00 and lowest at 4:00.At 3:01～6:00,the level of LTE4 was significantly higher in nocturnal asthmatic group than in non-nocturnal attacks group and normal controls(P<0.01).And in nocturnal asthmatic group the levels of LTE4 at 3:01～6:00 were significantly higher than those of at 8:01～11:00,at 15:01～18:00(P<0.05,P<0.01).Correlation analysis showed that the level of LTE4 at 3:01～6:00 was negatively correlated to the level of TPTEF/Te at 4:00 in nocturnal asthmatic group(P<0.01).The level of LTE4 at 3:01～6:00 was negatively correlated to the level of VPEF/Ve at 4:00 in nocturnal asthmatic group(P<0.05),too.Conclusion:In nocturnal asthmatic children who were 3～6 years old,tidal breathing lung function takes on circadian rhythm.LTE4 is a significatnt inflammation mediator in asthma,and may contribute to the nocturnal worsening of asthma.更多还原