【摘要】 目的:探讨血浆B型利钠肽(BNP)的水平与心功能分级之间的相关性。方法:采用美国博适床旁快速定量心力衰竭/心肌梗死诊断仪,测定239例慢性心力衰竭患者血浆中的BNP含量,在抗心力衰竭治疗2周后或出院时复测BNP,进行统计学分析。结果:血浆BNP水平与美国NYHA(纽约心脏学会)心功能不全(CHF)的分级标准密切相关(P<0.01),心功能不全越严重,BNP值越高,而且反映心功能不全程度较超声心动图EF值更敏感,所有经过抗心衰好转患者治疗2周后或出院时复测BNP,发现BNP都明显下降。结论:BNP值可作为较可靠的心功能不全的早期预测参考指标,也可作为判断心力衰竭严重程度和疗效以及预测预后的指标,而且操作简便,易于重复。更多还原

【Abstract】 Objective:To explore correlation between serum B type natriuretic peptide(BNP) level and heart failure(HF) classification.Methods:Serum BNP level in 239 patients was tested bedside by fast quantitative method.America Biosite Triagoe heart failure/myocardial infarction devisor.Furthermore blood BNP was retested after two weeks of anti HF treatment,and before all patients leave hospital,test and chisquare test were used in statistic analysis.Results:Serum BNP level correlates well with America NHYA CHF classification(P<0.01).The higher BNP level is at diagnosis,the worse heart failure is likely to be.Serum BNP test is more sensitive than EF level test on echocardiogram in reflecting CHF severity.After all patients were given anti HF treatment for two weeks,and before all patients leave hospital,all of their serum BNP level reduced obviously.Conclusion:Plasma BNP not only can be an early diagnosis index,but also can identify HF severity and efficacy and predict its outcome.The test procedures are simple and easily repetitive.更多还原