【摘要】 疾病的基因治疗需要安全、高效、靶向性的分子载体。通过对pRNA分子的结构和作用机理的研究,发现pRNA分子极易穿过细胞膜,有多个结合位点,能有效转导多个外源分子进入靶细胞,在体内几乎不引起免疫反应,而且可能通过设计多功能靶向复合物将疾病的检测和治疗有机地结合在一起,成为一种理想的基因治疗型载体。更多还原

【Abstract】 The molecular delivery vectors used in gene therapy need provide the features of safety,stability, efficiency and capacity. The current studies on the structure and action mechanism of pRNA, a packaging RNA of phageΦ29, showed that pRNA with multiple binding sites can through cell membrane easily and escort exogenous molecules to target cell, without inducing immune reaction. As an ideal nano-scale gene therapy vehicle, pRNA presents a promising application in delivering multiple therapeutic components to detect and treat human diseases.更多还原