【摘要】 介绍一组重要的转录因子、NF-κB(nuclear factor kappa B)的组成与分子结构,NF-κB抑制蛋白IκB、NF-κB激酶IKK对其活性的调节,NF-κB的激活机制,NF-κB对相当多数量的基因发挥中心性转录调节作用及其在免疫、炎症、细胞的生存、增殖分化和凋亡等方面的重要作用,NF-κB与疾病发生及疾病治疗的关系;展望NF-κB作为新靶点在新药设计与相关疾病治疗新策略方面的应用前景。更多还原

【Abstract】 NF-κB, a group of important transcription factors, are introduced and discussed here on several aspects: their component and molecular structure; their activity control by IκB and IKK, the mechanism of their activation; their important roles in transcriptional regulation for large numbers of genes; and their importance in immunity, inflammation, cell survival, proliferation and apoptosis. The analysis of the relation between NF-κB and disease occurrence, the analysis of the relation between NF-κB and disease therapy, and the application prospect of the new strategy regarding the novel drug design and correlative diseases therapy on the basis of NF-κB as the target, are also included.更多还原