【摘要】 多不饱和脂肪酸(PVFAs)不仅是细胞结构和功能的重要组成成分,而且对细胞生长、代谢、分化中的基因起调控作用。研究表明PUFAs可通过与肝脏核因子-4α、肝脏X受体α,β、过氧化物酶体增殖物激活受体(PPARs)等核受体直接作用,或与转录因子固醇调节元件结合蛋白1,2间接作用,以多种机制在分子水平上调节相关酶的基因转录。深化PUFAs基因调控机制的研究,对于营养、健康和医疗具有重要意义。更多还原

【Abstract】 Polyunstaurated fatty acids(PUFAs)not only are essential component of cells in maintaining function and composing organelle,but also control gene transcription of enzymes which are involved in differentiation,growth and metabolism in organisms.Resent studies have been shown that PUFA interact directly with nuclear receptors such as PPARs,LXR,HNF-4,other mechanism are indirect and rest with transcription factors such as SREBP.PUFA affect cell function through diverse pathways.The roles of such factors and PUFA in mediating the nuclear effects are addressed in order to elucidate the mechanism of PUFA in regulating gene expression.Further understanding of gene mechanism of regulation at the level of molecule would prompt the development of nutrition,health and medical treatment.更多还原