【摘要】 用4-乙烯基苄基胺与葡萄糖内酯反应合成了4-乙烯苄基葡萄糖酰胺单体(VBG)。以亚甲基双丙烯酰胺(BisA)为交联剂,用过硫酸钾(KPS)引发丙烯酰胺(AM)、衣康酸(IA)及4-乙烯苄基葡萄糖酰胺使之共聚,得到pH敏感含糖结构的三元共聚水凝胶。用核磁共振及红外光谱对单体和水凝胶的结构进行了表征,研究了不同水凝胶中药物的释放性能,以及pH值及盐的浓度对水凝胶中药物释放的影响。结果表明:水凝胶中药物在低pH值时或盐中药物释放显著下降,表明水凝胶对酸或盐有强烈的响应性。更多还原

【Abstract】 Sugar-containing monomer vinylbenzylglycosylallyamide(VBG)was synthesized by vinylbenzyl amine and δ-gluconolactone in dimethylformamide(DMF)solution。The sugar-based hydrogel was prepared by free radical crosslinking copolymerization of VBG,itaconic acid(IA)and acrylamide(AM).The release properties of Aspirin from xerogels matrices and from hydrogel in different pH solutions and different concentration NaCl solutions were studied respectively.The release mechanism of Aspirin was further confirmed by evaluating the n value in Peppas equation.The results indicated that the drug release increased with the increase of pH values and with the decrease of NaCl concentration.更多还原