【摘要】 迄今为止,我们对人类癫痫发作的机制还知之甚少,然而,普遍公认癫痫发作与神经元的异常同步放电密切相关。我们对匹罗卡品诱发的痫样放电大鼠皮层和海马脑电信号采用似然同步方法进行了分析,结果发现:从无痫样放电向连续性痫样放电转换时,左皮层—左海马(LC-LH)、右皮层—右海马(RC-RH)、左皮层—右皮层(LC-RC)、左海马—右海马(LH-RH)间的同步性显著增强(P<0.05);从连续性痫样放电向周期性痫样放电转换时,LC-LH、LH-RH间的同步性显著降低(P<0.01)。提示似然同步可以用于评估痫样放电中脑电信号同步的动力学特性并有助于理解其起源机制。更多还原

【Abstract】 The mechanisms leading to the occurrence of seizures in humans are still poorly understood.It is widely accepted,however,that the process of seizure generation is closely associated with an abnormal synchronization of neurons.In order to investigate this process,we have studied synchronization between different regions of the brain from intracranial EEG recordings of Pilocarpine-induced epileptic rat by Synchronization likelihood(SL).It was found that during the state of transition from non-epileptiform discharges to continuous-epileptiform discharges,synchronization between left-ECoG and left-EHG was significantly strengthened,and similar change had taken place between right-ECoG and right-EHGd;left-ECoG;and right-ECoG and left-EHG and right-EHG(P<0.05).During the state of transition from continuous-epileptiform discharges to period-epileptiform discharges,the synchronization was significantly weakened between left-ECoG and left-EHG,and similar change was noted between left-EHG and right-EHG(P<0.01).The results showed that SL might be used to assess the dynamics of synchronization and it might be helpful to understanding the mechanisms involving the origin of epileptiform discharge.更多还原