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替硝唑可生物降解聚乳酸缓释凝胶的制备

Preparation of Biodegradable and Sustained Release Gel of Tinidazole

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【Author】 Qin Yuyue~(1,4) Li Lin~1 Li Wei~2 Yuan Minglong~3 Zhu Yanxin~3 Guo Siyuan~11(College of Light Industry and Food Science,South China University of Technology,Guangzhou 510640,China)2(Key Lab.of Oral Biomedical Engineering,Sichuan University,Chengdu,610041,China)3(Sichuan Biochem-ZX Research Co.,Ltd,Chengdu 610041,China) 4(Kunming University of Science and Technology,Kunming 650224,China)

【机构】华南理工大学轻工与食品学院；四川大学口腔生物医学工程教育部重点实验室；四川琢新生物材料研究有限公司；华南理工大学轻工与食品学院广州510640；昆明理工大学生物与化学工程学院；昆明650224；广州510640；成都610041；

【摘要】采用聚乳酸[poly(DL-lactide)]制备替硝唑牙周缓释凝胶,考察聚合物分子量、浓度、溶剂和载药量等因素的影响,应用正交实验优选最佳制备工艺条件。结果表明,以N-甲基-2-吡咯烷酮(NMP)为溶剂,poly(DL-lactide)[DL-PLA]5 700浓度为30∶70,载药量为4%~6%时的工艺条件较优。更多还原

【Abstract】 The objective of this study was to prepare a biodegradable poly(DL-lactide) injectable gel of tinidazo1e.The formulation parameters evaluated in this study included polymer molecular weight,polymer concentration,solvent and drug loading,and orthogonal design was used to optimize the formulation.The preferable formulation was that 30%(w/w) poly(DL-lactide)(MW is(5 700)) dissolved in 70%(w/w) N-methyl-2-pyrrolidone with 4%-6%(w/w) tinidazo1e.更多还原

【关键词】聚乳酸；生物降解；替硝唑；凝胶；
【Key words】 Poly(DL-lactide) Biodegradation Tinidazo1e Gel；

【文献出处】生物医学工程学杂志 ,Journal of Biomedical Engineering , 编辑部邮箱 ,2007年01期

【分类号】R318.08
【被引频次】6
【下载频次】254

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