【摘要】 目的:了解罗格列酮(Rosiglitazone)处理果糖饲养的SD大鼠后对肝、肾功能,血常规的影响。方法:将24只成年健康SD大鼠随机分为A、B两组。A组持续喂高果糖饲料1月后再随机分为:①高果糖饲养组;②果糖饲养同时用罗格列酮处理组。B组喂标准饲料1月后随机分为:①对照组;②罗格列酮处理组。采用氧化酶法、放免法等技术方法测定大鼠的空腹血糖、血脂、胰岛素水平,肝功能,肾功能,血常规等指标。结果:与对照组相比:果糖饲养组大鼠直接胆红素、总胆红素、间接胆红素、血糖、胰岛素、总胆固醇、甘油三酯等指标均升高;而总蛋白、钾、钠、氯、胰岛素敏感指数等指标均下降,差异均具有统计学意义(P＜0．05)。而罗格列酮处理组中总胆红素、间接胆红素、尿酸和尿素/肌酐等指标均升高;而总蛋白、球蛋白、钾、钠、氨水平、甘油三酯、血常规细胞数、血红蛋白均下降,差异具有统计学意义(P＜0．05)。与果糖饲养组相比,果糖饲养罗格列酮处理组的总胆红素、直接胆红素、谷草转氨酶、间接胆红素、谷丙转氨酶、总胆固醇均升高;而胰岛素、甘油三酯、钙离子水平均下降差异均具有统计学意义,且前面三个指标的差异更明显(P＜0．05)。结论:罗格列酮在治疗过程中虽改善了果糖饲养SD大鼠所引起的胰岛素抵抗,但会加重肝肾功能障碍;对机体有一定的毒副作用。更多还原

【Abstract】 Objective:To assay the effect of Rosiglitazone on liver function,renal function and blood test of fruaose-fed SD rats dealt with PPAR-r ligand activator.Methods:24 mature healthy SD rats were randomly divided into two groups,group A and group B.The former was fed with fructose while the latter with standard forage.After a month,group A was redivided into highly fructose-fed group and fructose-fed and Rosiglitazone-treated group.Group B was also redivided into control group and Rosiglitazone-treated group.Then oxidation merase method and radioimmunoassay were used to detect some indexes such as serum glucose,blood lipid,insulin,liver function and renal function.Results:Compared with the control group,in the fructose- fed group,the levels of total bilirubin,direct and indirect bilirubin,blood glucose,insulin,total cholesterol and triglyceride were all elevated;while the total protein,potassium,natrium,chlorinum and insulin sensitivity index were descended.Compared with fructose-fed group,in fructose-fed and Rosiglitazone-treated group.some indexes like total bilirubin and lithic acid were elevated while some were descended like globulin,haematoglobin etc.The levels of total bilirubin,direct and indirect bilirubin,glutamic oxalacetic transaminase,glutamate-pyruvate transaminase and total cholesterol in fructose and Rosiglitazone-treated group were all higher than those in fructose-fed group.All above differences had statistical significance(P＜0.05).Conclusion:Rosiglitazone has side-effects on liver and kidney function and blood-test while improving insulin resistance induced by fructose feeding.更多还原