【摘要】 目的:观察异丙嗪对大鼠脑缺血损伤病理变化及神经功能的影响。方法:用改良的Longa氏法制备大鼠可再灌注大脑中动脉闭塞模型。大鼠随机分为缺血2 h后再灌注1、6 h,1、3、7 d对照组,并与之时间点相对应的异丙嗪组,对比观察各组脑缺血再灌注(IR)后的脑梗死灶体积并对神经功能缺损进行评分。结果:异丙嗪能显著改善IR 1 d后大鼠神经功能缺损症状及脑梗死灶(P<0.05)。结论:异丙嗪可阻抑大鼠局灶性脑缺血神经元的损伤并可发挥脑保护作用。更多还原

【Abstract】 Objective: To observe the effect of promethazine on local cerebral ischemia injury in rats.Methods: Modified Longa’s method was used to make rats’models with reversible middle cerebral artery occlusion(MCAO).Rats were randomly divided into 5 control groups(reperfusion for one hour、6 hours、one day、3 and 7 days following MCAO for 2 hours)and 5 promethazine groups with the same time point,then the infarction volume was measured and the neurologic dysfunction was scored.Results: Rats with infarctions and disorders in neurological function one day after IR.Scores and volume of infarctions reduced significantly in promethazine groups(P<0.05).Conclusion: Promethazine can prevent the injury of neuron after local cerebral ischemia in rats and produce the neuron-protective effects.更多还原