【摘要】 研究了转金属硫蛋白基因平菇对不同模型小鼠抗氧化能力的影响。结果表明:在小鼠饲料中掺入1%和3.16%的转金属硫蛋白基因平菇干粉(前者相当于50～60kg体重的人每日摄食鲜菇1kg),可明显增强受辐照小鼠血清SOD活性,降低其血清MDA含量;明显增强铅中毒小鼠血清SOD活性和抗活性氧能力;对衰老小鼠血清SOD活性的降低、MDA含量的升高无明显改善作用。结论:转金属硫蛋白基因平菇可提高受辐照和铅中毒小鼠的抗氧化能力,对增强D-半乳糖致衰老模型小鼠抗氧化能力无明显效果。更多还原

【Abstract】 Objective: Effects on anti-oxidization ability of model mice fed with transgenic metallothionein(MT) mushroom were studied in this paper. The results showed that the dried transgenic MT mushroom can significantly enhance the activity of SOD and reduce MDA content of radiated mice’s serum, and promote the activity of SOD and the ability of anti-active oxygen of lead poisoned mice when there is 1% or 3.16% MT mushroom mixed feed(the fomer corresponding to does of 1 kg/d to human whose weight is 50～60 kg). But there is no apparent effect on activity of SOD and MDA content in senile mice’s serum. Conclusion: Transgenic MT mushroom can evidently improve anti-oxidization ability of radiated mice and lead poisoned ones. But there is no advantageous effect on senile caused mice after intradermal injecting of D-galactose.更多还原