【摘要】 p53主要通过两条途径诱导细胞凋亡:p53作为转录因子,促进细胞凋亡的靶基因的表达上调,如PUMA、NOXA、PIDD、p53AIP1、COP1等,并通过这些蛋白参与内源和外源凋亡途径;另一方面,胞浆中的p53能转位到线粒体,激活内源性的线粒体途径,促进凋亡。后者已成为研究p53促凋亡机制的热点。本文就p53对转录非依赖活性诱导细胞凋亡途径的研究进展作一概述。更多还原

【Abstract】 p53 exerts its tumor-suppressing activity through complicated apoptotic mechanisms.Besides as atranscriptional factor for induction of multiple apoptotic-associated gene expression,p53 also triggers apoptosisthrough transcription-independent pathways.Cytosol p53 protein targets mitochondrial membrane throughinteraction with anti-or pro-apoptotic Bcl2 family members and induces the permeabilization of mitochondrialmembrane,which in turn initiates intrinsic mitochondria-mediated apoptotic pathway.This review focuses onthe mechanisms of its unexpected transcription-independent pro-death programs at mitochondria and high-lights the remarkable relationship between transcription-dependent and-independent apoptotic pathways.更多还原