【摘要】 心脏和血管的各种细胞分泌的生物活性分子,在心血管系统的功能稳态中具有重要的调节作用。新的活性肽的发现不仅提高了人们对疾病的认识,而且以新的活性多肽为靶点防治心血管疾病可能具有广阔的临床应用前景。心血管系统分泌的活性多肽不仅种类繁多,而且功能复杂,其功能复杂性不仅与其受体和受体亚型的组织分布和表达有关,还与其基因转录的剪切方式有关。此外,活性多肽的功能多样性还与其前体来源的其他片段以及活性多肽对受体的多选择性有关。更多还原

【Abstract】 Bioactive substances secreted from various cells of heart and vessels play a very important role in functional homeostasis of cardiovascular system. Discoveries of new bioactive peptides not only boost the cognition of the diseases, but also have extensive clinically prospectives in preventing and treating cardiovascular diseases. Bioactive peptides secreted from cardiovascular system have both multiple forms and diverse functions. The functional complexities of peptides correlated with receptor, distribution and expression of receptor subtype, and splicing of gene. In additon, the multifunctions of peptides are concerned with other fragments of the same peptide precursor, and with the choices of the same ligend for multiple receptors.更多还原