【摘要】 目的研究桃红通管胶囊对输卵管阻塞不孕症患者外周血白细胞介素-6(IL-6)和肿瘤坏死因子(TNF-α)含量变化及T细胞亚群的影响,并进一步探讨桃红通管胶囊抗输卵管阻塞不孕症的作用机理。方法将93例符合入选标准的输卵管阻塞不孕症患者,双盲双模拟随机分为治疗组(48例)和对照组(45例),93例均作输卵管通液术,治疗组服桃红通管胶囊,对照组服复方丹参片,疗程均为6个月经周期。从T细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)、IL-6、TNF-α含量变化等方面进行前瞻性对比治疗研究。结果输卵管阻塞不孕症患者存在免疫功能低下,血液IL-6、TNF-α含量明显升高,与健康人比较有显著性差异(P<0.05或P<0.01)。经治疗后,两组患者的各观察指标均有不同程度的改善,与治疗前比较有显著性差异(P<0.05及P<0.01);组间比较差异亦有显著性意义(P<0.05,P<0.01)。结论桃红通管胶囊对输卵管阻塞不孕的作用机理可能与提高机体的免疫功能、降低血液IL-6、TNF-α的含量有关。更多还原

【Abstract】 Objective To explore the effect of "Taohong Tongguan Capsule" on T-cell subgroup and IL-6 and TNF-α in patients with salpingemphraxistic infertility to better understand its pathogenesis. Methods Ninety-three cases were randomized in double-blinded way into treatment group and control group. The patient’s T lymphocyte subpopulation(CD3+, CD4+, CD8+, CD4+/CD8+), IL-6 and TNF-α were retrospectively analyzed. Results The immunologic function were decreased; levels of IL-6 and TNF-α increased obviously compared with healthy people (P < 0.05, P < 0.01). Both of the groups had improvement in different degrees after 2 courses of treatment(P < 0.05, P < 0.01). Conclusion "Taohong Tongguan Capsule" can obviously improve immune function and decrease IL-6 and TNF-α to treat salpingemphraxistic infertility.更多还原