【摘要】 目的探讨系统性红斑狼疮(SLE)患者血清抗β2糖蛋白I(β2GPI)抗体检测的临床意义。方法采用酶联免疫吸附试验(ELISA)半定量测定56例SLE患者及40名健康对照者血清抗β2GPI和抗心磷脂抗体(ACA)阳性率。结果SLE患者血清抗β2GPI和ACA阳性率分别为69.6%、80.4%,明显高于正常对照(P<0.01);SLE伴有血栓栓塞症状或病史者抗β2GPI为94.1%,高于无血栓栓塞症状的SLE患者(P<0.01)。结论SLE患者抗β2GPI的高表达与其临床症状,尤其是血栓栓塞症状具有一定的相关性。更多还原

【Abstract】 Objective To investigate the significance of measuring anti-β₂ glycoprotein I（β₂GPI） antibody in the systemic lupus erythematosus（SLE）. Methods The serum anti-β₂GPI and anti-cardiolipin antibodies（ACA） were measured by enzyme-linked immunosorbent assay（ELISA） in 56 patients with SLE and 40 healthy controls. Results The positive rates of anti-β₂GPI and ACA in SLE were 69.6% and 80.4%,significantly higher than that in control group（P<（0.01）;） The positive rates of anti-β₂GPI in SLE with thrombosis were 94.1%,higher than that of SLE without thrombosis（（P<0.01）.） Conclusions anti-β₂GPI antibody might be important in the mechanism of thrombosis in SLE.更多还原