【摘要】 目的探讨宫颈细胞DNA倍体分析在宫颈病变诊断中的价值。方法对接受宫颈癌普查的妇女用宫颈刷取材,液基薄层制片,制片后剩余细胞行流式细胞术DNA倍体分析;对其中290例患者做了活检病理诊断,其中非典型鳞状上皮增生（ASCUS）120例、低度宫颈上皮内瘤变（LSIL）90例、高度宫颈上皮内瘤变（HSIL）60例、鳞状上皮癌（SCC）20例。结果DNA异倍体在ASCUS、LSIL、HSIL、SCC组中的检出率分别为3.3%、31%、93%、100%;LSIL、HSIL、SCC三组与ASCUS组相比,P均<0.05;HSIL、SCC二组与LSIL组相比,P均<0.05;ASCUS、LSIL、HSIL、SCC组中,非DNA整倍体细胞者分别有25%、85.7%、96%、100%发生了2级宫颈上皮内瘤样病变（CIN₂）及以上级别的病变。结论DNA倍体分析可以明显提高CIN₂及以上级别宫颈病变的检出率。更多还原

【Abstract】 [Objective] To explore the the vnlue of DNA ploid analysis in cervical disease.[Methods] FCM was used to detect the cervical cells of 290 patients including atypical squamons cells of undetermined significance（ASCUS）120 ca- ses,low-grade squamons intraepithelial lesion（LSIL） 90 cases,high- grade squamous intraepithelial lesion（HSIL） 60 cases,squamous cell cancer （SCC） 20 cases.[Results] The rate of DNA heteroploid was 3.3% in ASCUS group,31% in LSIL group,93% in HSIL group,100% in SCC group.Heteroploid level of LSIL,HSIL in SCC group were different from that of ASCUS group（P<0.05）.Heteroploid level of HSIL in SCC group were different from that of LSIL group（P<0.05）.The rate of CIN₂ or above CIN₂ were 25%,85.7%,96%,100% in the the group of ASCUS,LSIL,HSIL,SCC with the heteroploid.[Conclusion] DNA ploid analysis can be successfully used to detect CIN₂ or above CIN₂ lesions.更多还原