【摘要】 目的观察阿司匹林和不同抗凝强度的华法林对非瓣膜病性房颤患者血栓栓塞并发症的预防效果和安全性。方法将确诊的非瓣膜病房颤患者135例,随机分为阿司匹林组、低强度华法林抗凝组和中强度华法林抗凝组,观察三组栓塞、出血和上腹部不适的发生率。结果低、中强度华法林抗凝组栓塞及上腹部不适的发生率明显低于阿司匹林组(P<0.05);不同强度华法林抗凝组血栓栓塞率比较差异无统计学意义(P>0.05);低强度华法林抗凝组轻微出血发生率明显低于中强度华法林抗凝组(P<0.05);三组均无严重出血发生。结论低强度华法林抗凝能降低非瓣膜病房颤血栓栓塞发生率,出血发生率低,安全性好。更多还原

【Abstract】 [Objective] To observe the prophylactic effect and safety of aspirin and different anticoagulate intensity of warfarin on the p revention of thromboembolism in patients with nonvalvular atrial fibrillation. [Method] 135 patients with nonvalvular atrial fibrillation were randomly divided into three groups. The first group was aspirin group,the second group was low intensity warfarin,the third group was middle intensity warfarin,the three groups received aspirin or warfarin. The incidence of the side-effects such as thrombo-embolism, hemorrhagic and midsection-discomfort were compared. [ Result ] The thrombo-embolism events in aspirin group was higher than that in two warfarin groups ( P < 0. 05). The thrombo-embolism events in two warfarin groups were no statistically significance( P > 0. 05). The minor bleeding events in middle intensity warfarin group was higher than that in low intensity warfarin group ( P < 0. 05 ). There was no serious bleeding in the three groups. [Conclusion] Low intensity warfarin can safely and remarkably reduce the incidence of thrombo-embolism in patients with non-valvular atrial fibrillation.更多还原