【摘要】 目的探讨尿激酶型纤溶酶原激活物受体(u-PAR)在人脑胶质瘤中的表达及其与临床病理分级的关系。方法应用流式细胞仪定量检测35例人脑胶质瘤标本中u-PAR水平,其中Ⅰ级8例,Ⅱ级9例,Ⅲ级9例,Ⅳ级6例,正常脑组织3例,应用直接染色法。结果u-PAR在人脑胶质瘤中的表达与病理分级相关,Ⅲ、Ⅳ级与Ⅰ、Ⅱ级和正常脑组织比较有高度统计学差异(P<0.01)。结论u-PAR表达与人脑胶质瘤病理分级相关,可作为判断其恶性程度和浸润性能的指标。更多还原

【Abstract】 [Objective] To investigate the pathologic significance of quantitation of urokinase-type plasminogen activator receptor in human brain glioma.[Methods] The specimens of 35 cases were quantitated by flow cytometry,including 8 cases in grade Ⅰ,9 cases in grade Ⅱ,9 cases in grade Ⅲ, 6 cases in grade Ⅳ,and 3 normal brain tissues.Direct staining was used in this study.[Results] The intensity of individual u-PAR expression in human glioma was correlated with the pathologic grade,and quantitative assay showed that u-PAR expression was higher in grade Ⅲ and grade Ⅳ than that in grade Ⅰ,gradeⅡ and normal brain(P<0.01).[Conclusion] The expression of u-PAR is positively correlated with the pathologic grade or pattern,and it can be the index of judging the malignant degree and infiltrative ability.更多还原