【摘要】 目的探讨老年急性冠脉综合征(ACS)患者血浆可溶性细胞间黏附分子-1(sICAM-1)和可溶性E-选择素(sE-selectin)的表达及阿托伐他汀对其影响。方法用ELISA法测定90例ACS患者和40例稳定性心绞痛(SAP)患者血浆sICAM-1和sE-selectin水平。同时将ACS患者随机分为高脂血症常规治疗组(A组)、高脂血症阿托伐他汀治疗组(B组)、非高脂血症常规治疗组(C组)、非高脂血症阿托伐他汀治疗组(D组);B、D组在常规治疗的基础上每日口服10 mg阿托伐他汀,共8周。检测各组治疗前后血浆sICAM-1和sE-selectin水平变化。结果ACS组sICAM-1和sE-selectin水平均高于SAP组(P<0.05,<0.01);阿托伐他汀治疗后,B、D组sICAM-1和sE-se-lectin水平较治疗前降低。结论血浆sICAM-1和sE-selectin水平与不同类型冠心病斑块稳定性有关,阿托伐他汀具有抑制细胞黏附分子表达,稳定动脉粥样硬化斑块的作用。更多还原

【Abstract】 [Objective]To explore the levels of plasma soluble ICAM-1 and soluble E-selectin and investigate the effects of atorvastatin on expression of them in elderly patients with acute coronary syndrome(ACS).[Methods]The concentrations of plasma sICAM-1 and sE-selectin were measured by ELISA in 90 patients with ACS and 40 patients with stable angina pectoris(SAP).90 patients with ACS were randomly divided into four groups including the control-hyperlipidemia group(A group),atorvastatin-hyperlipidemia group(B group),control-nonhyperlipidemia group(C group)and atorvastatin-nonhyperlipidemia group(D group).Patients in group B and D were treated with atorvastatin 10 mg per day for 8 weeks.Before and after treated,the concentrations of plasma sICAM-1 and sE-selectin were examined.[Results]The levels of plasma sICAM-1 and sE-selectin in patients with ACS were higher than those with SAP(P<0.05,<0.01).After being treated,the levels of sICAM-1 and sE-selectin were reduced siginificantly in group B and D.[Conclusion]Levels of plasma sICAM-1 and sE-selectin were higher in elderly patients with ACS than those with SAP,and atorvastatin may inhibit expression of cell adhesion molecule and stabilize the plaque of atherosclerosis.更多还原