【摘要】 目的探讨乳腺癌组织中PLK1、增殖细胞核抗原(PCNA)的表达及其临床意义。方法应用免疫组织化学S-P法检测32例乳腺癌患者癌组织及16例乳腺良性增生患者乳腺增生组织中PLK1、PCNA的表达。结果乳腺癌组织中PLK1、PCNA的阳性表达率分别为56、3%(18/32)、71.9%(23/32),PLK1表达与年龄、组织学类型、肿瘤大小、淋巴结状态、肿瘤分期及人类表皮生长因子受体-2(HER-2)的表达等因素无关(P均>0.05),与肿瘤分化程度、雌激素受体(ER)、孕激素受体(PR)表达有关(P均<0.05)。PCNA的表达与肿瘤分化程度、ER表达有关(P均<0.05);与年龄、组织学类型、肿瘤大小、淋巴结状态、PR及HER-2表达等因素无关(P均>0.05)。乳腺良性增生组织中PLK1、PCNA表达均为阴性或弱表达。结论PLK1在乳腺癌组织中表达具有一定肿瘤特异性,有望成为乳腺癌治疗的新靶点。更多还原

【Abstract】 [Objective] To study the expression of PLK1 and PCNA in breast carcinoma and its clinical significance.[Methods] The expression of PLK1 and PCNA was detected by S-P immunohistochemistry method in 32 cases of primary breast carcinoma and 16 cases of breast proliferative disease.The expression levels of PLK1 and PCNA in different age,pathological type,tumor size,histological grades,lymph-node metastasis,stage,the status of ER,PR and HER-2 were analyzed.[Results] The expression of PLK1 between primary breast carcinoma and breast proliferative disease was significantly different(P<0.05).The expression rate of LPLK1 and PCNA in primary breast was 56.3%(18/32) and 71.9%(23/32) respectively.PLK1 expression had no correlation with age,pathological type,tumor size,lymph node metastasis,stage and HER-2 status(P>0.05),but had correlation with differentiation degree,ER and PR(P<0.05).PCNA expression had correlation with differentiation degree,ER(P<0.05),no correlation with age,pathological type,tumor size,lymph node metastasis.PR and HER-2 status(P>0.05).The expression of PLK1 and PCNA was negative or week in breast proliferative disease.The expression of PLK1 in breast cancer was positively correlated with that of PCNA(P<0.05).[Conclusion] PLK1 may play an important role in the development and progression of breast cancer and may be a new target for cancer therapy.更多还原