【摘要】 目的:探讨前列腺增生(benign prostatic hyperplasia,BPH)造成患者膀胱出口梗阻(bladder outletobstruction,BOO)后膀胱逼尿肌中转化生长因子β(transforming growth factor-β,TGF-β)的表达变化。方法:BPH患者54例,分为逼尿肌稳定组(33例)和逼尿肌过度活动(detrusor overactivity,DO)组(21例)。对照组15例为同期在我院因膀胱癌施行开放手术的男性患者,应用免疫组化观察各组逼尿肌中TGF-β的表达。结果:BPH患者包括逼尿肌稳定组与DO组TGF-β的表达水平均明显高于对照组,在对照组、逼尿肌稳定组、DO组之间两两比较差异均有统计学意义(P<0.01)。结论:BPH造成BOO后逼尿肌中TGF-β的表达明显增高,这种变化可能与BOO后膀胱逼尿肌纤维化及DO相关。更多还原

【Abstract】 Objective: To investigate the changes of human detrusor transforming growth factor-β(TGF-β) after bladder outlet obstruction(BOO) induced by benign prostatic hyperplasia(BPH).Methods: Obstructive detrusor stability was found in 33 patients and obstructive detrusor overactivity in 21 patients; and bladder tumor in 15 men(control) who were operated on in the same period.TGF-β was measured by immunohistochemical staining.Results: The TGF-βlevels of the obstructive groups were much higher than those in the control group.There were significant differences among the three groups(P<0.01).Conclusion: The TGF-β level is significantly higher after BOO,which might be correlated with denervation supersensitivity and detrusor overactivity.更多还原