【摘要】 目的探讨焦虑症(AD)和抑郁症(CD)在事件相关电位(ERP)P300检测中的不同表现。方法收集符合CCMD-3诊断标准的37例焦虑症患者和32例抑郁症患者以及36例健康成人对照组(NC),使用美国仪器以及“听觉靶-非靶刺激序列”为诱发事件,完成P300检测。结果(1)AD组、CD组和NC组在靶潜伏期Pz脑区P3以及在靶波幅Pz脑区P2、P3和非靶波幅Pz脑区P2上均有显著差异(P<0.01)。(2)AD组主要成分P3表现为延迟,与NC组和CD组有极显著性差异(P<0.01)。(3)AD组和CD组靶波幅P3和非靶波幅P2均见降低,与NC组比较也有显著性差异(P<0.05)。结论P300有可能作为AD组和CD组辅助诊断的一个脑电生理学标志。更多还原

【Abstract】 Objective To investigate the changes of event related potentials P300 in patients with anxiety disorder (AD) and depression (CD).Methods An‘oddball’paradigm was used to elicit the auditory P300 in 37 patients with anxiety disorder (AD) 32 patients with depression (CD) and 36 normal controls (NC), by using a Nicolet Bravo Instrument.Results Significant difference of ERP-P300 among three groups were found with both latencies(Pz/P3) and amplitudes(Pz/ P3,Pz/P2)(P <0.01). Compared with the controls and AD group,CD group showed prolonged latency(P<0.01) and decreased amplitude(P<0.01). Compared with NC group, AD and CD patients showed decreased P3 amplitude from target and P2 amplitude from nontarget (P<0.05). Conclusion P300 could served as a physiological index for the diagnosis of anxiety disordor and dopression.更多还原