【摘要】 以间羟基苯甲酸和3,4-二氯三氟甲苯为起始原料,经过醚化、硝化和酰化三步反应合成虎威(氟黄胺草醚)。研究了虎威的合成工艺。试验表明,当温度为75℃~80℃、反应时间为3.5 h~4.5 h、摩尔比为n(三氟羧草醚)∶n(甲基磺酰胺)∶n(三氯氧磷)=1∶1.03∶1.62时,产品收率可达91.7%。对合成的氟磺胺草醚经过精制处理,其纯度为98.5%。该生产工艺可以降低成本,适于工业化生产。更多还原

【Abstract】 Fomesafen,was synthesized via condensation,nitration and acylation using m-hydroxybenzoic,3,4-dichloride-trifluoride-methylbenzene as starting reagents.The synthesis technology of fomesafen was researched.The experiment showed that at 75 ℃～80 ℃,a reaction time of 3.5 h～4.5 h, a molar ratio for n(acifluorfen)∶n(methylsulfoamide)∶n(trichloridephosphorusoxid)=1∶1.03∶1.62,the product yield was 91.7%.When the synthesized fomesafen was first put through a purification treatment,the purity was 98.5%.Both quality and yield were consistent across batches.Thus,this process provided a lower energy consumption production technology and was suitable for industrial scale manufacturing.更多还原