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Graves’病大鼠甲状腺细胞c-fos mRNA表达及益气养阴中药对其影响

Effect of Chinese Medicine Yiqiyangyin Tablet on the Expression of c-fos mRNA in Thyroid Cells of Rats with Graves’ Disease

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【作者】 王庆浩陈如泉卢全生

【Author】 Wang Qinghao1Chen Ruquan2Lu Quansheng31.Postdoctoral Position,Tianjin University of Traditional Chinese Medicine(Tianjian 300193,China)2.Endocrine Department of the Affiliated Hospital,Hubei College of Traditional Chinese Medicine(Wuhan Hubei 430061,China)3.Georgetown University Medical Center,Washington DC,USA 2007

【机构】 天津中医药大学博士后流动站湖北中医学院附属医院内分泌科Georgetown University Medical Center Washington DCUSA 2007天津300193湖北武汉430061

【摘要】 目的:研究Graves病大鼠甲状腺细胞c-fos mRNA表达及益气养阴中药对其影响。方法:Y.E菌尾静脉注射造成Graves病大鼠模型,益气养阴中药灌胃1月,原位杂交法观察其甲状腺细胞c-fos mRNA表达。结果:益气养阴中药组c-fos mRNA表达明显减弱。结论:益气养阴中药具有抑制甲状腺细胞生长的作用。

【Abstract】 Objective:To investigate the expression of c-fos mRNA in thyroid cells of model rats with Graves disease,and to study the effect of Chinese medicine Yiqiyangyin tablet on the expression of c-fos mRNA.Methods:The model rats with Graves’ disease were established by intravenous injection with Y.E bacterium. The rats were fed with Chinese medicine Yiqiyangyin tablets for one month.Researchers used the method of site hybridization to observe the expression of rats thyroid c-fos mRNA.Results:The expression of c-fos mRNA in Yiqiyangyin groups was lower obviously than that in other groups.Conclusion:Chinese medicine Yiqiyangyin tablet can restrain the growth of thyroid cells.

  • 【文献出处】 四川中医 ,Journal of Sichuan of Traditional Chinese Medicine , 编辑部邮箱 ,2007年05期
  • 【分类号】R285.5
  • 【被引频次】17
  • 【下载频次】157
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