【摘要】 目的:探讨不同病理类型子宫内膜癌中微血管密度与临床病理的关系。方法:采用S-P免疫组化染色法检测29例雌激素依赖型(Ⅰ型)子宫内膜癌及23例非雌激素依赖型(Ⅱ型)子宫内膜癌中CD34的表达以及计数微血管密度(M icro Vessel Density,MVD)。结果:Ⅰ型子宫内膜癌的MVD 76.9±31.2,Ⅱ型子宫内膜癌MVD131.65±35.63,有显著统计学差异(P<0.001)。低分化子宫内膜癌组MVD显著高于高、中分化子宫内膜癌组,差异具有统计学意义(P<0.05)。Ⅰ型子宫内膜癌中MVD和FIGO分期、子宫外转移和淋巴结转移有相关性。Ⅱ型子宫内膜癌中MVD与上述子宫内膜癌临床病理因素之间均无相关关系。结论:MVD与子宫内膜癌的发生有关,可作为Ⅰ型子宫内膜癌预后判断的参考指标。Ⅱ型子宫内膜癌可能在发病、发展、侵袭和转移过程中,具有不同于Ⅰ型子宫内膜癌的生物学模式。更多还原

【Abstract】 Objective: To investigate the relationship between micro-vessel density(MVD) and clinical pathological para-meters in different types of endometrial carcinoma.Methods: Twenty nine typeⅠand twenty three Ⅱ endometrial carcinoma patients’ MVD were detected by immunohisto-chemically staining CD34 protein with the biotinstreptavidin-peroxidase(SP) method.Results: MVD counted in type Ⅰ and type Ⅱ endometrial carcinoma respestively were 76.9±31.2 and 131.65±35.63.The difference was statistical signifiant.MVD of type Ⅰendometrial carcinoma was related to FIGO staging,pelvic metastasis and lymphatic metastasis.MVD of type Ⅱ endometrial carcinoma had no relationship with these parameters.Conclusion: MVD could be regarded as one of prognosis parameter for the type Ⅰ endometrial carcinoma.Comparing with the type Ⅰ endometrial carcinoma,the type Ⅱ ones may have a different biological pattern of epigenesis to invasion and metastasis.更多还原