【摘要】 目的探讨血清新蝶呤水平与SARS病程及严重程度的关系。方法应用ELISA方法检测129例SARS病人和156例健康献血者的血清新蝶呤含量。结果SARS病人血清新蝶呤水平在症状出现的首日即升高,129份急性期血清中新蝶呤含量平均值为(34.2±20.0)nmol/L,SARS恢复期病人及健康献血者血清中新蝶呤含量在正常范围,急性期血清新蝶呤含量是恢复期的5倍以上。SARS病人血清新蝶呤水平与发热期的长短及疾病的严重程度呈正相关。结论血清新蝶呤水平可作为SARS严重程度的早期指征之一。更多还原

【Abstract】 Objective To find the relationship between serum neopterin and severity of SARS.Method Neopterin concentrations were determined in serum samples from 129 severe acute respiratory syndrome(SARS)patients and 156 healthy blood donors by ELISA.Result In the patients with confirmed SARS,an early neopterin elevation was detected already at the day of onset of symptoms.The mean neopterin concentrations were(34.2±20.0)nmol/L in 129 acute sera of SARS patients,more than 5 times higher than convalescent sera,while the mean neopterin in convalescent sera and healthy controls were in normal range.Serum neopterin level in SARS patients was associated with fever period and thus the clinical progression of the disease.Conclusion Serum neopterin may allow early assessment of the severity of SARS.更多还原