【摘要】 目的探讨糖尿病合并支气管-肺部感染的病原学分布特点以及药物敏感性。方法2000-2005年住院诊断为糖尿病合并支气管-肺部感染患者46例,统计病原菌在不同疾病的分布特点和药敏纸片的结果。结果46例糖尿病合并支气管-肺部感染患者,普通细菌培养阳性21例,其中混合2种或以上细菌者12例,合并真菌感染者12例。分离的33株细菌中G-杆菌19株,占总分离株数的57.6%;其中肺炎克雷伯杆菌5株,占阴性杆菌的26.3%;嗜麦芽寡养单胞菌4株,占阴性杆菌的21.05%;铜绿假单胞菌、鲍蔓不动杆菌、阴沟肠杆菌、大肠埃希菌各2例,分别占阴性杆菌的10.5%;产吲哚黄杆菌、洋葱假单胞菌各1株,分别占阴性杆菌的5.1%。G+球菌14株,其中耐甲氧西林金黄色葡萄球菌9株,占阳性球菌的64.3%;粪肠球菌3例,占阳性球菌的21.4%;表皮葡萄球菌2例,占阳性球菌的14.21%。G+球菌均对万古霉素敏感,敏感率为100%;其次是替考拉宁和哌拉西林/舒巴坦,敏感率均为92.86%。G-对亚胺硫霉素和哌拉西林/舒巴坦敏感率为84.21%,其次为氧氟沙星78.95%,头孢哌酮为73.68%。结论糖尿病合并支气管-肺部感染的病原菌主要为阴性杆菌,也较容易合并耐甲氧西林金黄色葡萄球菌感染,应引起临床重视。更多还原

【Abstract】 Objective To examine the profiles of pathogenic microorganisms and their level of drug-resistance in patients suffered from diabetes and pulmonary infection. Methods Retrospective analysis of microbial infections in 46 patients suffered from diabetes and pulmonary infection was performed between 2000 and 2005. Results Among the 21 subjects with bacterial infection, 12 of them had infection by more than two types of pathogenic bacteria. 12 subjects had both bacterial and fungal infection. 19 out of 33 isolated bacterial species(57.6%) were Gram-negative bacilli. These included Klebsiella pneumoniae (5 isolates, 26.3%), Stenotrophomonas maltophilia (4 isolates, 21.5%), Aeruginosa (2 isolates), baumanii (2 isolates), Enterobacter cloacae (2 isolates), Escherichia coli (2 isolates), flavobacterium (1 isolate) and Pseudomonas cepacia (1 isolate). For the 14 isolated Gram-positive cocci, 9 isolates (64.3%) were methacillin-resistant Staphylococcu aureus (MRSA), 3 isolates (21.4%) were Enterococcus faecalis, and 2 isolates (14.2%) were Staphylococcus epedermidis. All Gram-positive cocci were sensitive to vancomycin. 92.8% of Gram-positive cocci were sensitive to Piperacillin / sulbacta. In contrast, the percentage of Gram-negative bacteria sensitive to Imipenem Piperacillin / sulbacta, Ofloxacin, and Cefoperazone was 84.21%, 78.95%, and 73.68%, respectively. Conclusion Most of the bacteria associated with pulmonary infection in diabetic patients are Gram-positive bacilli. MRSA infection is also commonly seen in these patients.更多还原