【摘要】 目的评价臭氧治疗外阴阴道假丝酵母菌病(VVC)和细菌性阴道病(BV)的有效性和安全性。方法将72例VVC随机分为试验组36例接受臭氧治疗和对照组36例接受达克宁栓治疗;BV试验组36例接受臭氧治疗,对照组36例接受甲硝唑栓治疗。均于治疗前、治疗后第3d观察临床症状及体征,并进行阴道分泌物病原学检查。结果VVC治疗结束后第3d,试验组和对照组的痊愈率分别为58.3%和61.1%,有效率分别为83.3%和88.9%,症状平均缓解时间分别为2.58d和2.36d,念珠菌阴转率分别为94.4%和100%。两组之间比较差异均无统计学意义(P>0.05);BV组治疗结束后第3d,试验组和对照组的痊愈率分别为61.1%和63.4%,有效率分别为80.6%和88.9%,症状缓解时间分别为3.72d和3.53d,阴道分泌物BV蓝检测阴转率均为100%。两组比较差异均无显著性(P>0.05)。144例受试者中无不良事件与严重不良事件发生。结论臭氧治疗VVC和BV安全、有效。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of ozone in the treatment of vulvovaginal candidiasis and bacterial vaginosis. Methods A randomized,controlled,open clinical trial was conducted and all the patients were divided into vulvovaginal candidiasis(VVC) group consisted 72 vulvovaginal candidiasis cases and bacterial vaginosis(BV) group consisted of 72 bacterial vaginosis cases.Thirty-six cases(treatment group) in VVC group were treated with ozone and another 36 cases(control group) were treated with miconazole nitrate suppositories.Thirty-six cases(control group) in the VC group were ozone and another 36 cases(control group) were treated with metronidazole suppositories.clinial manifestations three days before and after treatment observed and the vaginal secretions was pathogenically tested and the results were compared. Results Three days after the end of treatment,the cure rates in treatment group and control group of VVC group were 58.3% and 61.1% with the effective rates of 83.3% and 88.9%,respectively.The average symptom-relieving period was 2.58 days in treatment group and 2.36 days in control group.The pathogen-eliminating rates were 94.4% in treatmetn group and 100% in control group,without significant differences between these two groups(P>0.05).The cure rates in the treatment group adn control group of BV group were 61.1% and 63.4% with a effective rates of 80.6% and 88.9%,respetively.The average manifetation-relieving days were 3.72 days in the treatment group and 3.53 days in control group.The pathogen-eliminating rate were 100% in treatmetn group and 100% in control group,without showing significant differences between these two groups(P>0.05).There were no adverse events and severe adverse events happened in all these 144 cases. Conclusion Ozone is effective and safe in the treatment of vulvovaginal candidiasis and bacterial vaginosis.更多还原