【摘要】 目的观察单纯亚砷酸(AS2O3)联合维甲酸(ATRA)治疗急性早幼粒细胞白血病(APL)的不良反应及预防对策。方法对APL住院患者随机分两组,治疗组38例,单纯AS2O3+ATRA,从诱导治疗,巩固治疗到停药观察6年,对照组36例,AS2O3+ATRA+化疗(DA或MA),观察6年。结果治疗相关不良反应治疗组比对照组,在骨髓抑制,严重感染或败血症,肝肾功能损害,心肌损害,消化道反应等方面均较轻而少(P<0.01)。3年治疗相关死亡率为0,而对照组为16.7%(6/36)。结论治疗组相关不良反应等方面均显示令人满意效果。临床观察表明,单纯亚砷酸联合维甲酸治疗APL,具有协同增强作用,疗效高,治疗相关不良反应少,未见耐药性产生。不必加用化疗。更多还原

【Abstract】 Objective To observe pure arsenic trioxide (AS2O3) in combination with all-trans retinoic acid (ATRA) treatment of acute promyelocytic leukemia (APL) of the adverse reactions and the preventive countermeasures. Methods APL patients were randomly divided into two groups,treatment group,38 cases simply AS2O3+ATRA, From induction therapy,the treatment of consolidate to withholding be observed for six years;Control to 36 case,AS2O3+ATRA+ chemotherapy (DA or MA),6 years observation.Results Adverse reactions related to the treatment group than the control group,bone marrow suppression,severe infection or sepsis,liver and kidney damage,myocardial damage,gastrointestinal reactions were lighter and less.(P<0.01).Treatment-related mortality to treatment group for three-year was 0,while the control group was 16.7% (6/36).Conclusions Adverse reactions related to aspects of the treatment group showed satisfactory results.Clinical observations show that simply arsenic trioxide in combination with all-trans retinoic acid (ATRA) in the treatment of APL has enhanced synergy,and the effect is high,treatment-related adverse reactions is few,the resistance produced have not seen.No application of chemotherapy.更多还原