【摘要】 为了分析恶性滋养细胞肿瘤的发病、诊断及治疗后转归,探讨妊娠恶性滋养细胞肿瘤临床分期的特点及最佳治疗手段,对34例妊娠恶性滋养细胞肿瘤患者采用5-氟尿嘧啶(5-FU)、放线菌素D静脉联合化疗和(或)顺铂(DDP)、5-FU、多柔比星介入化疗及栓塞治疗,甲氨蝶呤、5-FU局部化疗或联合手术治疗等手段。结果:Ⅰ、Ⅱ期侵蚀性葡萄胎(IM)和绒癌(CC)患者,经采用联合化疗、介入治疗兼手术治疗治愈率100%,Ⅲ、Ⅳ期患者采用联合化疗、手术治疗亦可获得较满意的效果。初步研究结果提示,恶性滋养细胞肿瘤应早诊断早治疗,采取以化疗为主、手术治疗为辅的综合治疗手段,多数患者可以获得相对满意的治疗效果。更多还原

【Abstract】 This study was to analyze the pathogenesis,diagnosis,treatment and prognosis of GTN for probing the qualities of GTN clinical stages and the best therapy. Thirty-four cases of GTN underwent the following treatments: intravenous chemotherapy with 5-FU combined with actinomgcin D and/or interventional themotherapy and embolization with cisplatin for injection, 5-FU injection and doxorubicin hydrochloride for injection; local chemotherapy with methotrexate for injection and 5-FU injection and surgery. Patients suffering from stage Ⅰ, stage Ⅱ invasive mole and choriocarcinoma were treated with a comprehensive therapy including combined chemotherapy, interventional treatment and surgery and a cuarative rate of 100% was achieved.The effects of combined themotherapy and surgery were also satisfactory for stage Ⅲ and Ⅳ patients. In conclusion, GTN should be diagnosed and treated as early as possible.Reletively satisfying effects can be achieved with a comprehensive therapy including chemotherapy and surgery.更多还原