【摘要】 为了研究腹腔胃肠外间质瘤(gastrointestinal stromal tumor,EGIST)的临床病理、免疫组化、鉴别诊断和预后,对7例腹腔EGIST用光镜观察,免疫组化SP法检测CD117和CD34等的表达并进行随访。结果肿瘤直径平均17.2 cm,组织形态、免疫表型等与GIST相似,以短梭形细胞型为主,细胞密集,有不同程度的异形性,结构类似于平滑肌肿瘤。CD117阳性表达率为100%(7/7),CD34为71.4%(5/7)。随访6例,有4例术后2年内死亡。初步研究结果提示,腹腔EGIST好发于中老年人,具有GIST类似的组织学特征及免疫表型,恶性潜能高,预后较差,手术切除是主要的治疗方式。更多还原

【Abstract】 To evaluate the clinicopathological features and immunohistochemical profiles,differential diagnosis and prognosis of intra-abdominal extragastrointestinal stromal tumor(EGIST).Seven cases of EGIST were determined by light microscope.The expression of CD117 and CD34 was evolved with SP method.All patients were followed up.The mean tumor size was 17.2 cm in diameter.The tumor was similar with GIST in morphology and immunophenotype,composed of mainly short spindled cells.The tumor was cellular,with a variety of cell atypia,its growth pattern was similar with smooth muscle tumor.The tumors expressed CD117 100%(7/7),CD34 71.4%(5/7).Six cases were available for follow up,4 cases of those died over postoperative 2 years.Intra-abdominal EGIST is predilection for mid-old adult,identical to GIST in morphology and immunophenotype.Malignant potential is high,with poorly prognosis.Surgical excision is primary treatment.更多还原