【摘要】 为观察抗血管生成剂沙利度胺联合肝动脉化疗栓塞术(TACE)对血管内皮生长因子(VEGF)的影响。将68例患者随机分为A、B两组,A组采取单纯TACE治疗,B组采取口服沙利度胺与TACE联合治疗。治疗结束后采用ELISA方法检测VEGF的变化情况。结果示A组(TACE治疗)与B组(联合治疗)VEGF值分别为(362.18±226.16)和(148.56±122.32)ng/L,两者差异有统计学意义,P<0.01。初步研究结果提示,TACE治疗可诱导肝癌组织VEGF表达上调,这也是复发和转移的原因之一。而抗血管生成剂沙利度胺可有效控制VEGF的生成,为肝癌综合治疗提供新的有利武器。更多还原

【Abstract】 The objective of this study was to observe the influence of transcatheter hepatic artery chemoembolization(TACE)therapy combined with thalidomide on serum vascular endothelial growth factor(VEGF)leveles in the treatment of primary hepetic cance.Sixty-eight patients were divided into two groups,A and B.Group A adopted TACE treatment alone,Group B adopted thalidomide and TACE treatment.After the treatment,the enzyme linked immunosorbentassay(ELISA)was used to examine the change of VEGF.The VEGF levels of Group A(TACE treatment)and Group B(union treatment)were,(362.18±226.16)and(148.56±122.32)ng/L,respectively,P<0.01.In conclusion,TACE treatment may induce the liver cancer to increase VEGF expression,which is one of reasons for the recurrence and metastasis.Thalidomide may control VEGF production and be used in the liver cancer comprehensive therapy.更多还原