【摘要】 以10-羟基癸酸为起始原料,经过四氢铝锂还原、单边溴代、邻苯二甲酸二环乙酯(DHP)保护、格氏试剂偶联、脱DHP及乙酰化、臭氧化反应和Wittig反应,以17.9%的总收率合成了亚洲玉米螟性信息素(Z/E)-12-十四碳烯醇乙酸酯(1,2)和正十四碳醇乙酸酯(3)。与文献报道的方法相比,此方法更经济。更多还原

【Abstract】 Using 10-hydroxydecanoic acid as starting material,the sex pheromone of Ostrinia orientalis (Z/E)-12-tetradecene-1-ol acetate and n-tetradecyl acetate were synthesized in an overall yield of 17.9% through LiAlH4 reduction,mono-bromination,DHP protection,Grignard reagent coupling reaction,deprotect DHP and acetylation,Ozone reaction,and Wittig reaction. Compared with the reported methods,this method is more economical.更多还原