【摘要】 目的评价单用苯巴比妥治疗宁夏农村地区惊厥性癫痫病人的疗效和副作用。方法在固原、灵武、永宁、平罗、惠农、贺兰6个市县的162.2万人群中,对确诊的1095例惊厥性癫痫病人,采用苯巴比妥单药免费治疗1年,分别在第3、6、9和12个月对其疗效和副反应进行评估。结果77%发作次数明显减少,64%发作终止,经秩和检验,P<0.01;副作用随疗程的延长而减少,经χ2检验,前7项P<0.01。结论苯巴比妥单药治疗惊厥性癫痫发作,疗效肯定,副作用少,价廉、方便,适合在农村贫困地区应用,值得推广。更多还原

【Abstract】 Objective To evaluate the clinical value and side-effects of therapy for epilepsy by using mono phenobarbital in Ningxia rural areas.Methods Random cluster sampling was adopted to investigate epidemic epilepsy among the farmers in Guyuan,Lingwu,Yongning,Pingluo,Huinong and Helan.Totally,1622000 patients were investigated and 1095 cases of tonic-clonic seizures form of epilepsy were found.These cases were treated with antiepileptic drug-phenobarbital for one year.The curative effect and the side-effects were observed in 3rd,6th,9th and 12th months,respectively.Results The seizure was obviously decreased in 77% patients,and seizure was end in 64% patients.After rank sum test,there was significant difference(P<0.01).The side-effects reduced along with the treatment course extension,after chi-square test;there was significant difference(P<0.01) in first 7 items.26 cases(2.4%) were withdrawn in the group and 4 cases were died in the group.Conclusion This is an effective treatment to epilepsy by mono Phenobarbital with little side-effects,moderately-price and convenience.It is worth to spread and use in poor rural area.更多还原